General Information

  • ID:  hor005600
  • Uniprot ID:  P43306
  • Protein name:  GnRH-associated peptide 2
  • Gene name:  gnrh2
  • Organism:  Clarias gariepinus (North African catfish) (Silurus gariepinus)
  • Family:  GnRH family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Clarias (genus), Clariidae (family), Siluroidei (suborder), Siluriformes (order), Characiphysae (superorder), Otophysi, Ostariophysi (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  EIDSYSSPEISGEIKLCEAGECSYLRPLRTNILKSILIDTLARKFQKRK
  • Length:  49
  • Propeptide:  MVSVCRLLLVAALLLCLQAQLSFSQHWSHGWYPGGKREIDSYSSPEISGEIKLCEAGECSYLRPLRTNILKSILIDTLARKFQKRK
  • Signal peptide:  MVSVCRLLLVAALLLCLQAQLSFS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q91330-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor005600_AF2.pdbhor005600_ESM.pdb

Physical Information

Mass: 647086 Formula: C247H412N68O76S2
Absent amino acids: HMVW Common amino acids: ILS
pI: 8.75 Basic residues: 9
Polar residues: 15 Hydrophobic residues: 15
Hydrophobicity: -42.04 Boman Index: -10684
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 99.59
Instability Index: 7179.39 Extinction Coefficient cystines: 3105
Absorbance 280nm: 64.69

Literature

  • PubMed ID:  NA
  • Title:  NA